Details of the Target

General Information of Target

Target ID LDTP05514
Target Name Early activation antigen CD69 (CD69)
Gene Name CD69
Gene ID 969
Synonyms
CLEC2C; Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD antigen CD69
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIA
LSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATL
AVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTE
VSSMECEKNLYWICNKPYK
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
TTD ID
T48780
Uniprot ID
Q07108
DrugMap ID
TTPQE9F
Ensemble ID
ENST00000228434.7
HGNC ID
HGNC:1694
ChEMBL ID
CHEMBL3308911

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0166  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) V-ATPase proteolipid subunit family P27449
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-1 (CLDN1) Claudin family O95832
Myelin and lymphocyte protein (MAL) MAL family P21145
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) Nucleotide-sugar transporter family Q8TB61
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Uroplakin-1b (UPK1B) Tetraspanin (TM4SF) family O75841
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sphingosine 1-phosphate receptor 1 (S1PR1) G-protein coupled receptor 1 family P21453
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Protein reprimo (RPRM) Reprimo family Q9NS64
Transmembrane protein 190 (TMEM190) . Q8WZ59

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060