Details of the Target

General Information of Target

Target ID LDTP05513
Target Name Collagen alpha-1(XVI) chain (COL16A1)
Gene Name COL16A1
Gene ID 1307
Synonyms
Collagen alpha-1(XVI) chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWVSWAPGLWLLGLWATFGHGANTGAQCPPSQQEGLKLEHSSSLPANVTGFNLIHRLSLM
KTSAIKKIRNPKGPLILRLGAAPVTQPTRRVFPRGLPEEFALVLTLLLKKHTHQKTWYLF
QVTDANGYPQISLEVNSQERSLELRAQGQDGDFVSCIFPVPQLFDLRWHKLMLSVAGRVA
SVHVDCSSASSQPLGPRRPMRPVGHVFLGLDAEQGKPVSFDLQQVHIYCDPELVLEEGCC
EILPAGCPPETSKARRDTQSNELIEINPQSEGKVYTRCFCLEEPQNSEVDAQLTGRISQK
AERGAKVHQETAADECPPCVHGARDSNVTLAPSGPKGGKGERGLPGPPGSKGEKGARGND
CVRISPDAPLQCAEGPKGEKGESGALGPSGLPGSTGEKGQKGEKGDGGIKGVPGKPGRDG
RPGEICVIGPKGQKGDPGFVGPEGLAGEPGPPGLPGPPGIGLPGTPGDPGGPPGPKGDKG
SSGIPGKEGPGGKPGKPGVKGEKGDPCEVCPTLPEGFQNFVGLPGKPGPKGEPGDPVPAR
GDPGIQGIKGEKGEPCLSCSSVVGAQHLVSSTGASGDVGSPGFGLPGLPGRAGVPGLKGE
KGNFGEAGPAGSPGPPGPVGPAGIKGAKGEPCEPCPALSNLQDGDVRVVALPGPSGEKGE
PGPPGFGLPGKQGKAGERGLKGQKGDAGNPGDPGTPGTTGRPGLSGEPGVQGPAGPKGEK
GDGCTACPSLQGTVTDMAGRPGQPGPKGEQGPEGVGRPGKPGQPGLPGVQGPPGLKGVQG
EPGPPGRGVQGPQGEPGAPGLPGIQGLPGPRGPPGPTGEKGAQGSPGVKGATGPVGPPGA
SVSGPPGRDGQQGQTGLRGTPGEKGPRGEKGEPGECSCPSQGDLIFSGMPGAPGLWMGSS
WQPGPQGPPGIPGPPGPPGVPGLQGVPGNNGLPGQPGLTAELGSLPIEQHLLKSICGDCV
QGQRAHPGYLVEKGEKGDQGIPGVPGLDNCAQCFLSLERPRAEEARGDNSEGDPGCVGSP
GLPGPPGLPGQRGEEGPPGMRGSPGPPGPIGPPGFPGAVGSPGLPGLQGERGLTGLTGDK
GEPGPPGQPGYPGATGPPGLPGIKGERGYTGSAGEKGEPGPPGSEGLPGPPGPAGPRGER
GPQGNSGEKGDQGFQGQPGFPGPPGPPGFPGKVGSPGPPGPQAEKGSEGIRGPSGLPGSP
GPPGPPGIQGPAGLDGLDGKDGKPGLRGDPGPAGPPGLMGPPGFKGKTGHPGLPGPKGDC
GKPGPPGSTGRPGAEGEPGAMGPQGRPGPPGHVGPPGPPGQPGPAGISAVGLKGDRGATG
ERGLAGLPGQPGPPGHPGPPGEPGTDGAAGKEGPPGKQGFYGPPGPKGDPGAAGQKGQAG
EKGRAGMPGGPGKSGSMGPVGPPGPAGERGHPGAPGPSGSPGLPGVPGSMGDMVNYDEIK
RFIRQEIIKMFDERMAYYTSRMQFPMEMAAAPGRPGPPGKDGAPGRPGAPGSPGLPGQIG
REGRQGLPGVRGLPGTKGEKGDIGIGIAGENGLPGPPGPQGPPGYGKMGATGPMGQQGIP
GIPGPPGPMGQPGKAGHCNPSDCFGAMPMEQQYPPMKTMKGPFG
Target Bioclass
Other
Family
Fibril-associated collagens with interrupted helices (FACIT) family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.
Uniprot ID
Q07092
Ensemble ID
ENST00000373672.8
HGNC ID
HGNC:2193

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G151S .
CAL51 SNV: p.C959Y .
CASKI SNV: p.P1158S .
DU145 SNV: p.S1460C .
HCC15 SNV: p.A574D .
HCT15 SNV: p.K401R; p.P758S .
HGC27 SNV: p.P1166A DBIA    Probe Info 
HT115 SNV: p.S137N .
Ishikawa (Heraklio) 02 ER SNV: p.S174N .
JHH6 SNV: p.C956Y .
KMCH1 SNV: p.N689Y .
KMS27 SNV: p.P93S .
LN18 SNV: p.L807V .
LNCaP clone FGC SNV: p.F1169S; p.G1240Ter .
MCC13 Substitution: p.P1417F .
MDAMB157 SNV: p.E1530Ter .
MEWO SNV: p.P93S; p.P1128S .
MFE319 SNV: p.Q1209R .
MOLT4 SNV: p.A565T .
NCIH1666 SNV: p.R255L .
NCIH1793 SNV: p.K1080T .
NCIH358 SNV: p.R363L .
NUGC3 SNV: p.P663L .
SKNSH SNV: p.G1332V .
TE4 Insertion: p.G573QfsTer26 .
TE8 SNV: p.L638P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C156(2.27)  LDD3434  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HGC-27 C156(1.52)  LDD2356  [1]
 LDCM0023  KB03 AGS C156(0.86)  LDD2680  [1]
 LDCM0024  KB05 SK-N-MC C156(2.27)  LDD3434  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840