Details of the Target

General Information of Target

Target ID LDTP05499
Target Name Paired box protein Pax-8 (PAX8)
Gene Name PAX8
Gene ID 7849
Synonyms
Paired box protein Pax-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK
ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND
TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY
SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF
ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD
PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL
LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP
NSSLLSSPYYYSSTSRPSAPPTTATAFDHL
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Uniprot ID
Q06710
Ensemble ID
ENST00000263334.9
HGNC ID
HGNC:8622
ChEMBL ID
CHEMBL2362980

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 Deletion: p.E247LfsTer68
SNV: p.S70R		 .
COLO800 Deletion: p.E247LfsTer68 .
LNCaP clone FGC SNV: p.R64K; p.Q333Ter .
LS123 Insertion: p.S253PfsTer67 .
MELHO SNV: p.S70R .
MELJUSO Deletion: p.Y249PfsTer29 .
MEWO SNV: p.P235S
Substitution: p.G17K		 .
MOLT4 SNV: p.R287C .
NCIH1155 SNV: p.V122M .
NCIH358 SNV: p.K275Q .
NCIH716 Insertion: p.P252_S253insPP .
OVTOKO SNV: p.H377Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C45(3.39); C147(2.41)  LDD3365  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C124(1.26)  LDD2245  [1]
 LDCM0023  KB03 697 C124(1.40)  LDD2662  [1]
 LDCM0024  KB05 OVCAR-3 C45(3.39); C147(2.41)  LDD3365  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840