Details of the Target
General Information of Target
| Target ID | LDTP05466 | |||||
|---|---|---|---|---|---|---|
| Target Name | Dual specificity protein phosphatase 2 (DUSP2) | |||||
| Gene Name | DUSP2 | |||||
| Gene ID | 1844 | |||||
| Synonyms |
PAC1; Dual specificity protein phosphatase 2; EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase PAC-1 |
|||||
| 3D Structure | ||||||
| Sequence |
MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA GPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYL FLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAI GFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSF MGQLLQFETQVLCH |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
|
|||||
| Subcellular location |
Nucleus
|
|||||
| Function | Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IA-alkyne Probe Info |
 |
N.A. | LDD0166 | [1] | |