Details of the Target

General Information of Target

Target ID LDTP05431
Target Name Homeobox protein EMX2 (EMX2)
Gene Name EMX2
Gene ID 2018
Synonyms
Homeobox protein EMX2; Empty spiracles homolog 2; Empty spiracles-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFQPAPKRCFTIESLVAKDSPLPASRSEDPIRPAALSYANSSPINPFLNGFHSAAAAAAG
RGVYSNPDLVFAEAVSHPPNPAVPVHPVPPPHALAAHPLPSSHSPHPLFASQQRDPSTFY
PWLIHRYRYLGHRFQGNDTSPESFLLHNALARKPKRIRTAFSPSQLLRLEHAFEKNHYVV
GAERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLEEEGSDSQQKKKGTHHINRWRIATKQ
ASPEEIDVTSDD
Target Bioclass
Transcription factor
Family
EMX homeobox family
Subcellular location
Nucleus
Function
Transcription factor, which in cooperation with EMX1, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combination with OTX1/2 to specify cell fates in the developing central nervous system.
Uniprot ID
Q04743
Ensemble ID
ENST00000442245.5
HGNC ID
HGNC:3341

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.K208T .
ICC8 SNV: p.A34T .
KARPAS299 Deletion: p.H92TfsTer76
Insertion: p.P91QfsTer78		 .
KARPAS422 SNV: p.H77Y .
KU1919 SNV: p.H92N .
NCIH1155 SNV: p.A74E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		E216(0.00); E217(0.00); S219(0.00); S221(0.00)  LDD0245  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
OTU domain-containing protein 6A (OTUD6A) . Q7L8S5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E (EIF4E) Eukaryotic initiation factor 4E family P06730

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.