Details of the Target

General Information of Target

Target ID LDTP05423
Target Name P protein (OCA2)
Gene Name OCA2
Gene ID 4948
Synonyms
D15S12; P; P protein; Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MHLEGRDGRRYPGAPAVELLQTSVPSGLAELVAGKRRLPRGAGGADPSHSCPRGAAGQSS
WAPAGQEFASFLTKGRSHSSLPQMSSSRSKDSCFTENTPLLRNSLQEKGSRCIPVYHPEF
ITAEESWEDSSADWERRYLLSREVSGLSASASSEKGDLLDSPHIRLRLSKLRRCVQWLKV
MGLFAFVVLCSILFSLYPDQGKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASG
PSRPGREEHIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRETV
SISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYALIIFEIVHRTLAAMLGS
LAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG
RVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGA
ATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKE
PSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLHTFHRQISQE
DKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIW
LLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQR
LIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALAFGACLGG
NGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN
Target Bioclass
Transporter and channel
Family
CitM (TC 2.A.11) transporter family
Subcellular location
Melanosome membrane
Function
Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis.
Uniprot ID
Q04671
Ensemble ID
ENST00000353809.9
HGNC ID
HGNC:8101

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.L734Q .
CCK81 Deletion: p.K614SfsTer14 .
COLO678 SNV: p.T708I .
COLO792 SNV: p.A16T DBIA    Probe Info 
DAOY SNV: p.D372E .
HCC15 SNV: p.E693Ter .
HCC1954 SNV: p.A773T DBIA    Probe Info 
HUH7 SNV: p.V467A .
IGR39 SNV: p.R243H .
JHH6 SNV: p.I250T .
JURKAT SNV: p.V690I .
KNS42 SNV: p.G340S .
MDAMB436 SNV: p.M816I .
NCIH23 SNV: p.G795V .
NCIH661 SNV: p.D408Y .
NUGC3 SNV: p.V467A .
OVCAR8 SNV: p.G359R .
OVK18 Deletion: p.K614SfsTer14 .
RKO Deletion: p.K614SfsTer14
SNV: p.A424T		 .
RL952 Deletion: p.D486TfsTer13;p.K614SfsTer14
SNV: p.Y215H		 .
SG231 SNV: p.F804L .
TOV21G SNV: p.P12H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C457(1.48)  LDD3337  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C51(2.85)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C51(3.67)  LDD2660  [1]
 LDCM0024  KB05 MSTO-211H C457(1.48)  LDD3337  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840