Details of the Target

General Information of Target

Target ID LDTP05390
Target Name cAMP-responsive element modulator (CREM)
Gene Name CREM
Gene ID 1390
Synonyms
cAMP-responsive element modulator; Inducible cAMP early repressor; ICER
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQL
PSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPS
YRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQI
SNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETELAP
SHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAA
KECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY
Target Bioclass
Transcription factor
Family
BZIP family
Subcellular location
Cytoplasm; Nucleus
Function
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.; [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Uniprot ID
Q03060
Ensemble ID
ENST00000337656.8
HGNC ID
HGNC:2352

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.41  LDD0402  [1]
STPyne
 Probe Info  		K311(6.53)  LDD2217  [2]
DBIA
 Probe Info  		C98(2.71)  LDD3331  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C98(1.08)  LDD2250  [3]
 LDCM0023  KB03 A-375 C98(1.96)  LDD2672  [3]
 LDCM0024  KB05 MKN-1 C98(2.71)  LDD3331  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) C5-methyltransferase family Q9Y6K1
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) CAMK Ser/Thr protein kinase family Q9BUB5
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2) Tyr protein kinase family Q01974
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuron-specific calcium-binding protein hippocalcin (HPCA) Recoverin family P84074
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Homeobox protein VENTX (VENTX) . O95231
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Hippocalcin-like protein 1 (HPCAL1) Recoverin family P37235
Neurocalcin-delta (NCALD) Recoverin family P61601
Neuronal calcium sensor 1 (NCS1) Recoverin family P62166
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840