Details of the Target

General Information of Target

Target ID LDTP05365
Target Name Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1)
Gene Name CACNB1
Gene ID 782
Synonyms
CACNLB1; Voltage-dependent L-type calcium channel subunit beta-1; CAB1; Calcium channel voltage-dependent subunit beta 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSA
ESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVP
VQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR
LGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLK
GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA
EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG
KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP
NPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYP
SSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGT
PPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
Target Bioclass
Transporter and channel
Family
Calcium channel beta subunit family
Subcellular location
Cell membrane, sarcolemma
Function
Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.
Uniprot ID
Q02641
Ensemble ID
ENST00000344140.6
HGNC ID
HGNC:1401
ChEMBL ID
CHEMBL3988638

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P329T .
786O Deletion: p.A373_Q379del .
COLO320 SNV: p.R66C .
DEL SNV: p.T201P .
HEC1 SNV: p.S481N .
JURKAT SNV: p.T201A .
MDAMB453 SNV: p.E291K .
MFE319 SNV: p.Y468H .
NCIH1299 SNV: p.T499S .
SW1116 SNV: p.P221S .
SW756 SNV: p.E305K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		E86(0.00); R87(0.00)  LDD0246  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTP-binding protein GEM (GEM) RGK family P55040
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) Calcium channel alpha-1 subunit (TC 1.A.1.11) family Q13936

The Drug(s) Related To This Target

Approved
Click To Hide/Show 27 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amiodarone Small molecular drug DB01118
Amlodipine Small molecular drug DB00381
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Dronedarone Small molecular drug DB04855
Drotaverine Small molecular drug DB06751
Enflurane Small molecular drug DB00228
Ergocalciferol Small molecular drug DB00153
Ethanol Small molecular drug DB00898
Ibutilide Small molecular drug DB00308
Levomenthol Small molecular drug DB00825
Manidipine Small molecular drug DB09238
Miconazole Small molecular drug DB01110
Nicardipine Small molecular drug DB00622
Nilvadipine Small molecular drug DB06712
Nimodipine Small molecular drug DB00393
Nitrendipine Small molecular drug DB01054
Phenytoin Small molecular drug DB00252
Ranolazine Small molecular drug DB00243
Spironolactone Small molecular drug DB00421
Topiramate Small molecular drug DB00273
Trimebutine Small molecular drug DB09089
Verapamil Small molecular drug DB00661
Bioallethrin . DB13746
Butamben . DB11148
Calcium Citrate . DB11093
Fish Oil . DB13961
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cilnidipine Small molecular drug DB09232
Mibefradil Small molecular drug DB01388
Azelnidipine . DB09230
Benidipine . DB09231
Efonidipine . DB09235

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.