Details of the Target

General Information of Target

Target ID LDTP05331
Target Name Myocyte-specific enhancer factor 2A (MEF2A)
Gene Name MEF2A
Gene ID 4205
Synonyms
MEF2; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST
DMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINE
EFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSML
SPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIG
ATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNTQR
ISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLS
LGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQ
QQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSP
IVLGRPPNTEDRESPSVKRMRMDAWVT
Target Bioclass
Transcription factor
Family
MEF2 family
Subcellular location
Nucleus
Function
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
Uniprot ID
Q02078
Ensemble ID
ENST00000354410.9
HGNC ID
HGNC:6993

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C96(1.06)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C96(1.06)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C96(1.20)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C96(1.21)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C96(1.00)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C96(1.31)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C96(0.92)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C96(1.24)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C96(1.08)  LDD1560  [1]
 LDCM0367  CL1 HEK-293T C96(0.87)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C96(1.01)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C96(1.00)  LDD1575  [1]
 LDCM0374  CL105 HEK-293T C96(1.02)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C96(0.89)  LDD1579  [1]
 LDCM0378  CL109 HEK-293T C96(0.92)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C96(0.94)  LDD1584  [1]
 LDCM0383  CL113 HEK-293T C96(1.05)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C96(1.12)  LDD1588  [1]
 LDCM0387  CL117 HEK-293T C96(1.00)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C96(0.95)  LDD1592  [1]
 LDCM0392  CL121 HEK-293T C96(0.91)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C96(0.83)  LDD1597  [1]
 LDCM0396  CL125 HEK-293T C96(0.95)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C96(1.04)  LDD1601  [1]
 LDCM0400  CL13 HEK-293T C96(1.02)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C96(1.10)  LDD1605  [1]
 LDCM0405  CL18 HEK-293T C96(1.18)  LDD1609  [1]
 LDCM0407  CL2 HEK-293T C96(0.85)  LDD1611  [1]
 LDCM0413  CL25 HEK-293T C96(0.88)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C96(1.02)  LDD1618  [1]
 LDCM0419  CL30 HEK-293T C96(1.10)  LDD1623  [1]
 LDCM0426  CL37 HEK-293T C96(0.86)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C96(1.00)  LDD1636  [1]
 LDCM0439  CL49 HEK-293T C96(1.00)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C96(0.88)  LDD1645  [1]
 LDCM0445  CL54 HEK-293T C96(1.17)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C96(0.94)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C96(0.87)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C96(1.01)  LDD1657  [1]
 LDCM0458  CL66 HEK-293T C96(1.30)  LDD1661  [1]
 LDCM0466  CL73 HEK-293T C96(0.77)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C96(0.97)  LDD1670  [1]
 LDCM0471  CL78 HEK-293T C96(1.00)  LDD1674  [1]
 LDCM0479  CL85 HEK-293T C96(0.90)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C96(0.78)  LDD1683  [1]
 LDCM0485  CL90 HEK-293T C96(0.94)  LDD1688  [1]
 LDCM0492  CL97 HEK-293T C96(0.87)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C96(0.85)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C96(0.85)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402