Details of the Target

General Information of Target

Target ID LDTP05300
Target Name Keratin, type II cytoskeletal 2 oral (KRT76)
Gene Name KRT76
Gene ID 51350
Synonyms
KRT2B; KRT2P; Keratin, type II cytoskeletal 2 oral; Cytokeratin-2P; CK-2P; K2P; Keratin-76; K76; Type-II keratin Kb9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYN
LGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGGSYGGGFGGGRGVGSGFGGAG
GFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVK
AQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYISF
LCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQ
YEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKK
QNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDV
EIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGG
SSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGS
SSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK
Target Bioclass
Other
Family
Intermediate filament family
Function Probably contributes to terminal cornification.
Uniprot ID
Q01546
Ensemble ID
ENST00000332411.2
HGNC ID
HGNC:24430

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D199(0.99); E205(0.98)  LDD2208  [1]
HHS-465
 Probe Info  		N.A.  LDD2240  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		1.30  LDD0136  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Forkhead box protein R2 (FOXR2) . Q6PJQ5
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 20 (KRT20) Intermediate filament family P35900
Keratin, type I cytoskeletal 25 (KRT25) Intermediate filament family Q7Z3Z0
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 39 (KRT39) Intermediate filament family Q6A163
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Lebercilin-like protein (LCA5L) LCA5 family O95447
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Developmental pluripotency-associated protein 3 (DPPA3) . Q6W0C5
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
LIM domain transcription factor LMO4 (LMO4) . P61968

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
3 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.