Details of the Target

General Information of Target

Target ID LDTP05290
Target Name Myosin regulatory light chain 2, atrial isoform (MYL7)
Gene Name MYL7
Gene ID 58498
Synonyms
MYL2A; MYLC2A; Myosin regulatory light chain 2, atrial isoform; MLC-2a; MLC2a; Myosin light chain 2a; Myosin regulatory light chain 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRKAGTRGKVAATKQAQRGSSNVFSMFEQAQIQEFKEAFSCIDQNRDGIICKADLRET
YSQLGKVSVPEEELDAMLQEGKGPINFTVFLTLFGEKLNGTDPEEAILSAFRMFDPSGKG
VVNKDEFKQLLLTQADKFSPAEVEQMFALTPMDLAGNIDYKSLCYIITHGDEKEE
Target Bioclass
Other
Uniprot ID
Q01449
Ensemble ID
ENST00000223364.7
HGNC ID
HGNC:21719
ChEMBL ID
CHEMBL3831286

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C164(2.24)  LDD2282  [1]
Acrolein
 Probe Info  		C164(0.00); H169(0.00)  LDD0222  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa C164(0.00); H169(0.00)  LDD0222  [2]
 LDCM0022  KB02 C-4-II C164(2.24)  LDD2282  [1]
 LDCM0023  KB03 C-4-II C164(4.48)  LDD2699  [1]
 LDCM0024  KB05 C-4-II C164(11.42)  LDD3116  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
TOX high mobility group box family member 4 (TOX4) . O94842
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial coiled-coil domain protein 1 (MCCD1) . P59942
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.