Details of the Target

General Information of Target

Target ID LDTP05288
Target Name AMP deaminase 3 (AMPD3)
Gene Name AMPD3
Gene ID 272
Synonyms
AMP deaminase 3; EC 3.5.4.6; AMP deaminase isoform E; Erythrocyte AMP deaminase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQ
KELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLP
TPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQY
LGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEH
QEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKEL
KSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFD
GLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARM
VKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIF
RSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDK
SPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF
LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSL
STDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYY
KEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN
Target Bioclass
Enzyme
Family
Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family
Function AMP deaminase plays a critical role in energy metabolism.
Uniprot ID
Q01432
Ensemble ID
ENST00000396553.7
HGNC ID
HGNC:470
ChEMBL ID
CHEMBL2912

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.Y679C .
COLO792 SNV: p.A26S .
EFO27 SNV: p.Y560C .
HCT15 SNV: p.K654N; p.Q712R .
IGR1 SNV: p.K271I .
MCC13 SNV: p.P111S .
MDAMB453 SNV: p.Q626Ter .
NCIH2170 SNV: p.A158D .
P31FUJ SNV: p.P111H .
TGBC52TKB SNV: p.I762T .
YSCCC SNV: p.L648V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C756(1.10)  LDD3313  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		C747(0.00); C47(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C47(0.00); C747(0.00)  LDD0037  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
SF
 Probe Info  		N.A.  LDD0028  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 IGROV-1 C756(1.32)  LDD2398  [1]
 LDCM0023  KB03 HG-3 C56(3.11)  LDD2772  [1]
 LDCM0024  KB05 Hs 936.T C756(1.10)  LDD3313  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AMP deaminase 1 (AMPD1) Adenosine and AMP deaminases family P23109
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931