Details of the Target

General Information of Target

Target ID LDTP05261
Target Name Pregnancy-specific beta-1-glycoprotein 9 (PSG9)
Gene Name PSG9
Gene ID 5678
Synonyms
PSG11; Pregnancy-specific beta-1-glycoprotein 9; PS-beta-G-9; PSBG-9; Pregnancy-specific glycoprotein 9; PS34; Pregnancy-specific beta-1 glycoprotein B; PS-beta-B; Pregnancy-specific beta-1-glycoprotein 11; PS-beta-G-11; PSBG-11; Pregnancy-specific glycoprotein 11; Pregnancy-specific glycoprotein 7; PSG7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPLPAPSCTQRITWKGLLLTASLLNFWNPPTTAEVTIEAQPPKVSEGKDVLLLVHNLPQ
NLPGYFWYKGEMTDLYHYIISYIVDGKIIIYGPAYSGRETVYSNASLLIQNVTRKDAGTY
TLHIIKRGDETREEIRHFTFTLYLETPKPYISSSNLNPREAMEAVRLICDPETLDASYLW
WMNGQSLPVTHRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRSDPVTLNLLPKLP
IPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPGVKRPIENRILILPSV
TRNETGPYQCEIRDRYGGLRSNPVILNVLYGPDLPRIYPSFTYYRSGENLDLSCFTESNP
PAEYFWTINGKFQQSGQKLFIPQITRNHSGLYACSVHNSATGKEISKSMTVKVSGPCHGD
LTESQS
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, CEA family
Subcellular location
Secreted
Function
Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1. The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells. Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset. Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells. May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6.
Uniprot ID
Q00887
Ensemble ID
ENST00000244293.11
HGNC ID
HGNC:9526

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.E404V .
HCT116 SNV: p.G376R .
MFE319 SNV: p.S226G .
NCIH1793 SNV: p.V223L .
NCIH1944 SNV: p.L20H .
NCIH2172 SNV: p.T198S .
WM115 SNV: p.R336K .
WM2664 SNV: p.R336K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C417(3.76)  LDD2284  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CAL-120 C417(3.76)  LDD2284  [1]
 LDCM0023  KB03 CAL-120 C417(2.56)  LDD2701  [1]
 LDCM0024  KB05 CAL-120 C417(3.36)  LDD3118  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840