Details of the Target

General Information of Target

Target ID LDTP05241
Target Name Homeobox protein Hox-C5 (HOXC5)
Gene Name HOXC5
Gene ID 3222
Synonyms
HOX3D; Homeobox protein Hox-C5; Homeobox protein CP11; Homeobox protein Hox-3D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHG
VDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKE
EQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYL
TRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL
Target Bioclass
Transcription factor
Family
Antp homeobox family
Subcellular location
Nucleus
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot ID
Q00444
Ensemble ID
ENST00000312492.3
HGNC ID
HGNC:5127

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C76(1.89)  LDD3402  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 REC-1 C76(1.79)  LDD2568  [1]
 LDCM0023  KB03 REC-1 C76(1.80)  LDD2985  [1]
 LDCM0024  KB05 REC-1 C76(1.89)  LDD3402  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Pre-B-cell leukemia transcription factor 1 (PBX1) TALE/PBX homeobox family P40424
Pre-B-cell leukemia transcription factor 2 (PBX2) TALE/PBX homeobox family P40425
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019