Details of the Target
General Information of Target
| Target ID | LDTP05221 | |||||
|---|---|---|---|---|---|---|
| Target Name | Rho GTPase-activating protein 4 (ARHGAP4) | |||||
| Gene Name | ARHGAP4 | |||||
| Gene ID | 393 | |||||
| Synonyms |
KIAA0131; RGC1; RHOGAP4; Rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4; p115 |
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| 3D Structure | ||||||
| Sequence |
MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE
LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCT KARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQ GLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILP RAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSD PGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSW TQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEG IFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGE LLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCF GPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGD AQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERAS SDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPC TSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSP SPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH |
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| Target Bioclass |
Other
|
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| Subcellular location |
Cytoplasm
|
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| Function | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CAOV3 | SNV: p.E60K | . | |||
| LS180 | SNV: p.R73C | . | |||
| MOLT4 | SNV: p.G82E | IA-alkyne Probe Info | |||
| RL | SNV: p.A167P | DBIA Probe Info | |||
| SW620 | SNV: p.T407P | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C34(28.49) | LDD0209 | [1] | |
|
4-Iodoacetamidophenylacetylene Probe Info |
 |
C855(0.00); C527(0.00); C569(0.00) | LDD0038 | [2] | |
|
IA-alkyne Probe Info |
 |
C855(0.00); C527(0.00); C569(0.00); C330(0.00) | LDD0036 | [2] | |
|
Lodoacetamide azide Probe Info |
 |
C34(0.00); C855(0.00); C527(0.00); C569(0.00) | LDD0037 | [2] | |
Competitor(s) Related to This Target
References