Details of the Target

General Information of Target

Target ID LDTP05182
Target Name Serine protease HTRA3 (HTRA3)
Gene Name HTRA3
Gene ID 94031
Synonyms
PRSP; Serine protease HTRA3; EC 3.4.21.-; High-temperature requirement factor A3; Pregnancy-related serine protease
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
Target Bioclass
Enzyme
Family
Peptidase S1C family
Subcellular location
Secreted
Function
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
Uniprot ID
P83110
Ensemble ID
ENST00000307358.7
HGNC ID
HGNC:30406

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KU1919 SNV: p.A331G .
MEWO SNV: p.F340L .
NCIH2172 Deletion: p.R109AfsTer25
SNV: p.E371Ter		 .
P31FUJ SNV: p.A125S .
SUIT2 SNV: p.I359V .
SW948 SNV: p.P20T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C126(2.60)  LDD2412  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Karpas-299 C126(2.60)  LDD2412  [1]
 LDCM0023  KB03 Karpas-299 C126(3.21)  LDD2829  [1]
 LDCM0024  KB05 Karpas-299 C126(2.57)  LDD3246  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840