Details of the Target

General Information of Target

Target ID LDTP05169
Target Name Protein ENTREP3 (ENTREP3)
Gene Name ENTREP3
Gene ID 10712
Synonyms
C1orf2; COTE1; FAM189B; Protein ENTREP3; Endosomal transmembrane epsin interactor 3; Protein COTE1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTT
TESIKRSCPSWAGFSLAFSGVVGIVSWKRPFTLVISFFSLLSVLCVMLSMAGSVLSCKNA
QLARDFQQCSLEGKVCVCCPSVPLLRPCPESGQELKVAPNSTCDEARGALKNLLFSVCGL
TICAAIICTLSAIVCCIQIFSLDLVHTLAPERSVSGPLGPLGCTSPPPAPLLHTMLDLEE
FVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQAT
LFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSVD
YVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAAR
SCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPHP
ASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLARC
PSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAPD
PSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSLN
GGSRETGL
Target Bioclass
Other
Family
ENTREP family
Subcellular location
Membrane
Uniprot ID
P81408
Ensemble ID
ENST00000350210.6
HGNC ID
HGNC:1233

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.E515K .
CCK81 Deletion: p.P396HfsTer44
SNV: p.T256A;p.C257Y;p.W431C		 .
HS578T SNV: p.P564L .
JURKAT SNV: p.C257Y .
KP4 Deletion: p.H233QfsTer88 .
MCC13 SNV: p.Q561Ter .
MCC26 SNV: p.S213Ter .
MELHO SNV: p.P226Q .
MOLT4 SNV: p.L514F .
NCIH716 Substitution: p.Y279V .
TYKNU SNV: p.W617C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C436(3.08)  LDD3419  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0024  KB05 SH-4 C436(3.08)  LDD3419  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WW domain-containing oxidoreductase (WWOX) Short-chain dehydrogenases/reductases (SDR) family Q9NZC7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019