Details of the Target

General Information of Target

Target ID LDTP05139
Target Name Sushi repeat-containing protein SRPX (SRPX)
Gene Name SRPX
Gene ID 8406
Synonyms
ETX1; Sushi repeat-containing protein SRPX
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSHPRYKDTPWCSPI
KVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRC
PTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPP
RIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYT
VYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSP
ARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLG
MLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVD
KHGMDKERYVSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT
Target Bioclass
Other
Subcellular location
Cell surface
Function May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.
Uniprot ID
P78539
Ensemble ID
ENST00000378533.4
HGNC ID
HGNC:11309

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.L371P .
HT1197 SNV: p.L447F .
K562 SNV: p.P410T .
KARPAS422 SNV: p.R119Ter .
MELHO SNV: p.F288L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C367(1.06)  LDD3316  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C133(2.55); C57(2.13); C367(2.82)  LDD2250  [1]
 LDCM0023  KB03 A101D C133(4.18); C57(2.58); C367(4.48)  LDD2667  [1]
 LDCM0024  KB05 MEL167 C367(1.06)  LDD3316  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840