Details of the Target

General Information of Target

Target ID LDTP05126
Target Name Iroquois-class homeodomain protein IRX-4 (IRX4)
Gene Name IRX4
Gene ID 50805
Synonyms
IRXA3; Iroquois-class homeodomain protein IRX-4; Homeodomain protein IRXA3; Iroquois homeobox protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
Target Bioclass
Transcription factor
Family
TALE/IRO homeobox family
Subcellular location
Nucleus
Function Likely to be an important mediator of ventricular differentiation during cardiac development.
Uniprot ID
P78413
Ensemble ID
ENST00000231357.7
HGNC ID
HGNC:6129

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P124L .
A2058 SNV: p.F489C .
COLO792 Substitution: p.P278L .
EFO21 SNV: p.P4T .
FTC133 SNV: p.L286R .
HT1197 SNV: p.S242A .
HT29 SNV: p.W457Ter .
HUH7 SNV: p.A379T .
JURKAT SNV: p.A121V .
KELLY SNV: p.A380T .
KMCH1 SNV: p.S101I; p.E203Q .
KYSE180 SNV: p.E226K .
KYSE410 SNV: p.P400L .
MEC1 Substitution: p.P4L .
MFE319 SNV: p.P265S .
NALM6 SNV: p.R305W .
NCIH1993 SNV: p.W438C .
NUGC3 SNV: p.A379T .
OVK18 SNV: p.E363D .
SNU1 SNV: p.S24R .
TE4 SNV: p.A380S; p.A423V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C214(2.82)  LDD2227  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C214(2.82)  LDD2227  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264