Details of the Target

General Information of Target

Target ID LDTP05124
Target Name Iroquois-class homeodomain protein IRX-5 (IRX5)
Gene Name IRX5
Gene ID 10265
Synonyms
IRX2A; IRXB2; Iroquois-class homeodomain protein IRX-5; Homeodomain protein IRX-2A; Homeodomain protein IRXB2; Iroquois homeobox protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPG
YNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNA
TRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWT
PRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAASGCERLQGPPTPAG
KETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGP
HPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCP
PCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGH
LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGM
SDI
Target Bioclass
Transcription factor
Family
TALE/IRO homeobox family
Subcellular location
Nucleus
Function
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
Uniprot ID
P78411
Ensemble ID
ENST00000320990.9
HGNC ID
HGNC:14361

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.R269PfsTer99 DBIA    Probe Info 
AN3CA SNV: p.D286G .
EFO27 SNV: p.L17P .
HL60 SNV: p.Y291S .
IM95 SNV: p.A167V .
Ishikawa (Heraklio) 02 ER SNV: p.S40T .
MCC26 Substitution: p.G37N .
MOLT4 SNV: p.R461W .
NCIH2172 Substitution: p.A73S .
NCIH661 SNV: p.L97F .
OCUG1 SNV: p.P267T .
SKNSH SNV: p.Q223K .
SKOV3 SNV: p.H290R .
SW1271 SNV: p.G50C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C229(2.57)  LDD3337  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C229(1.02)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C229(1.05)  LDD1497  [2]
 LDCM0024  KB05 MSTO-211H C229(2.57)  LDD3337  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402