Details of the Target

General Information of Target

Target ID LDTP05018
Target Name DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L)
Gene Name POLR2L
Gene ID 5441
Synonyms
DNA-directed RNA polymerases I, II, and III subunit RPABC5; RNA polymerases I, II, and III subunit ABC5; DNA-directed RNA polymerase III subunit L; RNA polymerase II 7.6 kDa subunit; RPB7.6; RPB10 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK
Target Bioclass
Enzyme
Family
Archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family
Subcellular location
Nucleus
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Uniprot ID
P62875
Ensemble ID
ENST00000322028.5
HGNC ID
HGNC:9199

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y62(7.49)  LDD0257  [1]
STPyne
 Probe Info  		K67(2.44)  LDD0277  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
DNA-directed RNA polymerase II subunit RPB4 (POLR2D) Eukaryotic RPB4 RNA polymerase subunit family O15514
Proteasome subunit alpha type-6 (PSMA6) Peptidase T1A family P60900
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Nucleus accumbens-associated protein 1 (NACC1) . Q96RE7
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Coilin (COIL) Coilin family P38432
Protein FAM217B (FAM217B) FAM217 family Q9NTX9
RNA polymerase II-associated protein 1 (RPAP1) RPAP1 family Q9BWH6
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Sperm-associated antigen 5 (SPAG5) . Q96R06

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270