General Information of Target

Target ID LDTP04933
Target Name Lysozyme C (LYZ)
Gene Name LYZ
Gene ID 4069
Synonyms
LZM; Lysozyme C; EC 3.2.1.17; 1,4-beta-N-acetylmuramidase C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRA
TNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRD
PQGIRAWVAWRNRCQNRDVRQYVQGCGV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 22 family
Subcellular location
Secreted
Function Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
TTD ID
T10586
Uniprot ID
P61626
DrugMap ID
TTAOZBW
Ensemble ID
ENST00000261267.7
HGNC ID
HGNC:6740

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info 
100.00  LDD0444  [1]
DBIA
 Probe Info 
C146(2.41); C83(3.14)  LDD3336  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC108 C146(1.65)  LDD2381  [2]
 LDCM0023  KB03 ICC108 C146(1.59)  LDD2798  [2]
 LDCM0024  KB05 MONO-MAC-6 C146(2.41); C83(3.14)  LDD3336  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysozyme C (LYZ) Glycosyl hydrolase 22 family P61626

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aspartic Acid Small molecular drug DB00128
Sucrose Small molecular drug DB02772
Propyl Alcohol . DB03175
Investigative
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(R)-propylene Glycol . DB02159
(S)-aspartimide . DB03487
4-methyl-umbelliferyl-n-acetyl-chitobiose . DB02759
Arsanilic Acid . DB03006
Cu-cyclam . DB03189
Dodecyl Sulfate . DB03967
Methylumbelliferyl Chitotriose . DB04268
N-acetyl-beta-d-glucosaminyl-(1->4)-n-acetyl-beta-d-glucosamine . DB03013
P-toluenesulfonic Acid . DB03120
Triacetylchitotriose . DB04194
Undeca-37-diene-13711-tetracarbaldehyde . DB06912

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840