Details of the Target

General Information of Target

Target ID LDTP04930
Target Name Neurocalcin-delta (NCALD)
Gene Name NCALD
Gene ID 83988
Synonyms
Neurocalcin-delta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGD
ASKFAEHVFRTFDANGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISKAE
MLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNRDGKLSLEEFIRGAKSDPSIV
RLLQCDPSSAGQF
Target Bioclass
Other
Family
Recoverin family
Function May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Uniprot ID
P61601
Ensemble ID
ENST00000220931.11
HGNC ID
HGNC:7655

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K174(8.33)  LDD0275  [1]
DBIA
 Probe Info  		C185(10.63)  LDD3344  [2]
IA-alkyne
 Probe Info  		C185(14.80)  LDD1707  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell C185(14.80)  LDD1707  [3]
 LDCM0023  KB03 Karpas-299 C185(8.39)  LDD2829  [2]
 LDCM0024  KB05 NCI-H146 C185(10.63)  LDD3344  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Glutathione peroxidase 7 (GPX7) Glutathione peroxidase family Q96SL4
Phospholipase A and acyltransferase 2 (PLAAT2) H-rev107 family Q9NWW9
Tryptase gamma (TPSG1) Peptidase S1 family Q9NRR2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 7 (GOLGA7) ERF4 family Q7Z5G4
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leukemia inhibitory factor (LIF) LIF/OSM family P15018
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Fibroblast growth factor 6 (FGF6) Heparin-binding growth factors family P10767
Keratin, type II cytoskeletal 6A (KRT6A) Intermediate filament family P02538
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Myeloid-derived growth factor (MYDGF) MYDGF family Q969H8
Serglycin (SRGN) Serglycin family P10124
Anosmin-1 (ANOS1) . P23352
Complement C1q tumor necrosis factor-related protein 2 (C1QTNF2) . Q9BXJ5
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592
Lymphocyte antigen 6 complex locus protein G6d (LY6G6D) . O95868
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264