Details of the Target

General Information of Target

Target ID LDTP04912
Target Name Protein max (MAX)
Gene Name MAX
Gene ID 4149
Synonyms
BHLHD4; Protein max; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR
AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN
SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
Target Bioclass
Transcription factor
Family
MAX family
Subcellular location
Nucleus
Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Uniprot ID
P61244
Ensemble ID
ENST00000246163.2
HGNC ID
HGNC:6913
ChEMBL ID
CHEMBL1250363

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.H28R .
CAL51 SNV: p.R60Q .
NCIH358 SNV: p.E14D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SF
 Probe Info  		N.A.  LDD0028  [1]
STPyne
 Probe Info  		N.A.  LDD0009  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA ligase 3 (LIG3) ATP-dependent DNA ligase family P49916
Ferritin heavy chain (FTH1) Ferritin family P02794
Serine/threonine-protein kinase VRK3 (VRK3) CK1 Ser/Thr protein kinase family Q8IV63
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor AP-2-alpha (TFAP2A) AP-2 family P05549
Transcription factor Dp-1 (TFDP1) E2F/DP family Q14186
Transcription factor E2F6 (E2F6) E2F/DP family O75461
Endothelial PAS domain-containing protein 1 (EPAS1) . Q99814
Forkhead box protein K2 (FOXK2) . Q01167
Max dimerization protein 1 (MXD1) . Q05195
MAX gene-associated protein (MGA) . Q8IWI9
Max-interacting protein 1 (MXI1) . P50539
Myc proto-oncogene protein (MYC) . P01106
N-myc proto-oncogene protein (MYCN) . P04198
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) G-protein coupled receptor 3 family Q9UBS5
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Elongation factor 1-delta (EEF1D) EF-1-beta/EF-1-delta family P29692
Progranulin (GRN) Granulin family P28799
Core histone macro-H2A.1 (MACROH2A1) Histone H2A family O75367
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
DNA repair protein XRCC1 (XRCC1) . P18887
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Methyl-CpG-binding protein 2 (MECP2) . P51608
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Protein unc-45 homolog A (UNC45A) . Q9H3U1
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764