Details of the Target

General Information of Target

Target ID	LDTP04894
Target Name	Cyclin-dependent kinases regulatory subunit 1 (CKS1B)
Gene Name	CKS1B
Gene ID	1163
Synonyms	CKS1; Cyclin-dependent kinases regulatory subunit 1; CKS-1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIH EPEPHILLFRRPLPKKPKK
Target Bioclass	Other
Family	CKS family
Function	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Uniprot ID	P61024
Ensemble ID	ENST00000308987.6
HGNC ID	HGNC:19083

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 6 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
STPyne Probe Info	K30(10.00); K34(7.10)	LDD0277	[1]
HHS-475 Probe Info	Y7(1.43)	LDD0264	[2]
ATP probe Probe Info	K26(0.00); K11(0.00); K4(0.00)	LDD0199	[3]
m-APA Probe Info	H3(0.00); H36(0.00)	LDD2231	[4]
1c-yne Probe Info	N.A.	LDD0228	[5]
Acrolein Probe Info	N.A.	LDD0217	[6]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[6]
LDCM0116	HHS-0101	DM93	Y7(1.43)	LDD0264	[2]
LDCM0117	HHS-0201	DM93	Y7(1.21)	LDD0265	[2]
LDCM0118	HHS-0301	DM93	Y7(1.43)	LDD0266	[2]
LDCM0119	HHS-0401	DM93	Y7(1.61)	LDD0267	[2]
LDCM0120	HHS-0701	DM93	Y7(1.24)	LDD0268	[2]
LDCM0107	IAA	HeLa	H36(0.00); H21(0.00)	LDD0221	[6]
LDCM0109	NEM	HeLa	N.A.	LDD0223	[6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 10 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
E3 ubiquitin-protein ligase XIAP (XIAP)	IAP family	P98170
Cyclin-dependent kinase 1 (CDK1)	CMGC Ser/Thr protein kinase family	P06493
Cyclin-dependent kinase 2 (CDK2)	CMGC Ser/Thr protein kinase family	P24941
Cyclin-dependent kinase 3 (CDK3)	CMGC Ser/Thr protein kinase family	Q00526
Neuronal-specific septin-3 (SEPTIN3)	Septin GTPase family	Q9UH03
Tripartite motif-containing protein 14 (TRIM14)	TRIM/RBCC family	Q14142
Tripartite motif-containing protein 49 (TRIM49)	TRIM/RBCC family	P0CI25
Zinc finger protein RFP (TRIM27)	TRIM/RBCC family	P14373
S-phase kinase-associated protein 2 (SKP2)	.	Q13309
Tripartite motif-containing protein 49C (TRIM49C)	.	P0CI26

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1)				LZTS family	Q9Y250

Transcription factor

Click To Hide/Show 11 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Homeobox protein CDX-4 (CDX4)	Caudal homeobox family	O14627
DNA-binding protein Ikaros (IKZF1)	Ikaros C2H2-type zinc-finger protein family	Q13422
Zinc finger protein Aiolos (IKZF3)	Ikaros C2H2-type zinc-finger protein family	Q9UKT9
Steroidogenic factor 1 (NR5A1)	Nuclear hormone receptor family	Q13285
Paired box protein Pax-6 (PAX6)	Paired homeobox family	P26367
AT-rich interactive domain-containing protein 5A (ARID5A)	.	Q03989
Homeobox protein MOX-1 (MEOX1)	.	P50221
Paired box protein Pax-5 (PAX5)	.	Q02548
Proto-oncogene c-Rel (REL)	.	Q04864
Transcription factor 4 (TCF4)	.	P15884
Zinc finger and BTB domain-containing protein 9 (ZBTB9)	.	Q96C00

Other

Click To Hide/Show 19 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Apoptosis-stimulating of p53 protein 1 (PPP1R13B)	ASPP family	Q96KQ4
Protein chibby homolog 2 (CBY2)	Chibby family	Q8NA61
Cancer/testis antigen family 45 member A1 (CT45A1)	CT45 family	Q5HYN5
Cyclin-C (CCNC)	Cyclin family	P24863
Dynein regulatory complex subunit 4 (GAS8)	DRC4 family	O95995
Protein INCA1 (INCA1)	INCA family	Q0VD86
Keratin-associated protein 10-9 (KRTAP10-9)	KRTAP type 10 family	P60411
Keratin-associated protein 5-9 (KRTAP5-9)	KRTAP type 5 family	P26371
Mediator of RNA polymerase II transcription subunit 12-like protein (MED12L)	Mediator complex subunit 12 family	Q86YW9
Ropporin-1A (ROPN1)	Ropporin family	Q9HAT0
Speedy protein E4 (SPDYE4)	Speedy/Ringo family	A6NLX3
Small ubiquitin-related modifier 5 (SUMO1P1)	Ubiquitin family	G2XKQ0
Coiled-coil domain-containing protein 120 (CCDC120)	.	Q96HB5
Doublecortin domain-containing protein 2 (DCDC2)	.	Q9UHG0
Heat shock factor 2-binding protein (HSF2BP)	.	O75031
Keratinocyte proline-rich protein (KPRP)	.	Q5T749
Mirror-image polydactyly gene 1 protein (MIPOL1)	.	Q8TD10
SERTA domain-containing protein 1 (SERTAD1)	.	Q9UHV2
SERTA domain-containing protein 2 (SERTAD2)	.	Q14140

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Fluoxetine				Small molecular drug	DB00472

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
28-bis[Oxido(Oxo)Vanadio]-11135577999-undecaoxopentavanadoxane-28-diium				.	DB02681

References

1	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
2	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
5	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
6	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.