Details of the Target

General Information of Target

Target ID LDTP04881
Target Name Synaptosomal-associated protein 25 (SNAP25)
Gene Name SNAP25
Gene ID 6616
Synonyms
SNAP; Synaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERI
EEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARV
VDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDR
IMEKADSNKTRIDEANQRATKMLGSG
Target Type
Successful
Target Bioclass
Transporter and channel
Family
SNAP-25 family
Subcellular location
Cytoplasm, perinuclear region
Function
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.
TTD ID
T71023
Uniprot ID
P60880
DrugMap ID
TTYQWA0
Ensemble ID
ENST00000254976.7
HGNC ID
HGNC:11132
ChEMBL ID
CHEMBL2364159

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.S25L .
ONS76 SNV: p.D110G .
OVK18 SNV: p.M14L .
RKO SNV: p.R142Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.20  LDD0403  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.20  LDD0403  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Syntaxin-1A (STX1A) Syntaxin family Q16623
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-1 (CPLX1) Complexin/synaphin family O14810
Syntaxin-11 (STX11) Syntaxin family O75558
Ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2) . Q9BRT2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Botulinum Toxin Type A BiotechDrug DB00083
Botulinum Toxin Type A . D0D1RM
Letibotulinumtoxina . DB16820

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.