Details of the Target
General Information of Target
| Target ID | LDTP04794 | |||||
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| Target Name | Transmembrane protease serine 3 (TMPRSS3) | |||||
| Gene Name | TMPRSS3 | |||||
| Gene ID | 64699 | |||||
| Synonyms |
ECHOS1; TADG12; Transmembrane protease serine 3; EC 3.4.21.-; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein |
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| 3D Structure | ||||||
| Sequence |
MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI
LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR LGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHA AVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATS FGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT |
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| Target Bioclass |
Enzyme
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| Family |
Peptidase S1 family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro).
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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AMP probe Probe Info |
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N.A. | LDD0200 | [1] | |