Details of the Target

General Information of Target

Target ID LDTP04792
Target Name Krueppel-like factor 3 (KLF3)
Gene Name KLF3
Gene ID 51274
Synonyms
BKLF; Krueppel-like factor 3; Basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLMFDPVPVKQEAMDPVSVSYPSNYMESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQME
PVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVP
LSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSM
QVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQ
PGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWK
FARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis.
Uniprot ID
P57682
Ensemble ID
ENST00000261438.10
HGNC ID
HGNC:16516

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 Insertion: p.Q227AfsTer37 .
JURKAT SNV: p.S100F .
LNCaP clone FGC SNV: p.E171D .
MFE319 SNV: p.M180V .
RKO Insertion: p.Q227AfsTer37 .
RL952 Deletion: p.P226RfsTer52 .
SNGM Deletion: p.K106NfsTer21 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K288(0.00); K291(0.00); Y290(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010