Details of the Target
General Information of Target
| Target ID | LDTP04779 | |||||
|---|---|---|---|---|---|---|
| Target Name | Transcription factor SOX-8 (SOX8) |
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| Gene Name | SOX8 | |||||
| Gene ID | 30812 | |||||
| Synonyms |
Transcription factor SOX-8 |
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| 3D Structure | ||||||
| Sequence |
MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAA
DERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKL ADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAK AGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGA KPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPPEPG QAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGS CSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLL NGLALPPAHSPTSHWDQPVYTTLTRP |
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| Target Bioclass |
Transcription factor
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| Subcellular location |
Nucleus
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| Function | Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K138(10.00) | LDD0277 | [1] | |
|
DBIA Probe Info |
 |
C67(5.87) | LDD3401 | [2] | |
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HHS-475 Probe Info |
 |
Y124(0.21); Y169(1.50) | LDD0264 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0116 | HHS-0101 | DM93 | Y124(0.21); Y169(1.50) | LDD0264 | [3] |
| LDCM0117 | HHS-0201 | DM93 | Y124(0.29); Y169(1.46) | LDD0265 | [3] |
| LDCM0118 | HHS-0301 | DM93 | Y124(0.18); Y169(1.47) | LDD0266 | [3] |
| LDCM0119 | HHS-0401 | DM93 | Y124(0.27); Y169(1.58) | LDD0267 | [3] |
| LDCM0120 | HHS-0701 | DM93 | Y124(0.42); Y169(1.51) | LDD0268 | [3] |
| LDCM0022 | KB02 | RD | C67(4.41) | LDD2567 | [2] |
| LDCM0023 | KB03 | RD | C67(4.99) | LDD2984 | [2] |
| LDCM0024 | KB05 | RD | C67(5.87) | LDD3401 | [2] |
References