Details of the Target

General Information of Target

Target ID LDTP04748
Target Name ADP-ribosylation factor-like protein 4C (ARL4C)
Gene Name ARL4C
Gene ID 10123
Synonyms
ARL7; ADP-ribosylation factor-like protein 4C; ADP-ribosylation factor-like protein 7; ADP-ribosylation factor-like protein LAK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAK
GISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLEEAKTELHKVTKFAENQGT
PLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPACAIIGEGLTEGMDKLYEMIL
KRRKSLKQKKKR
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Arf family
Subcellular location
Cell projection, filopodium
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.
Uniprot ID
P56559
Ensemble ID
ENST00000339728.6
HGNC ID
HGNC:698

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C64(1.10)  LDD1571  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [2]
Lodoacetamide azide
 Probe Info  		C64(0.00); C85(0.00)  LDD0037  [2]
NAIA_4
 Probe Info  		C64(0.00); C85(0.00)  LDD2226  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C64(1.10)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C64(1.00)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C64(1.17)  LDD1575  [1]
 LDCM0374  CL105 HEK-293T C64(1.08)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C64(0.93)  LDD1579  [1]
 LDCM0378  CL109 HEK-293T C64(0.96)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C64(1.22)  LDD1584  [1]
 LDCM0383  CL113 HEK-293T C64(0.96)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C64(1.12)  LDD1588  [1]
 LDCM0387  CL117 HEK-293T C64(1.13)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C64(1.12)  LDD1592  [1]
 LDCM0392  CL121 HEK-293T C64(1.01)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C64(0.95)  LDD1597  [1]
 LDCM0396  CL125 HEK-293T C64(0.84)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C64(1.08)  LDD1601  [1]
 LDCM0400  CL13 HEK-293T C64(1.07)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C64(1.22)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C64(1.33)  LDD1611  [1]
 LDCM0413  CL25 HEK-293T C64(0.97)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C64(1.04)  LDD1618  [1]
 LDCM0426  CL37 HEK-293T C64(1.05)  LDD1630  [1]
 LDCM0439  CL49 HEK-293T C64(0.96)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C64(1.18)  LDD1645  [1]
 LDCM0453  CL61 HEK-293T C64(0.96)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C64(1.15)  LDD1657  [1]
 LDCM0466  CL73 HEK-293T C64(1.11)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C64(1.15)  LDD1670  [1]
 LDCM0479  CL85 HEK-293T C64(0.93)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C64(0.93)  LDD1683  [1]
 LDCM0492  CL97 HEK-293T C64(1.09)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C64(1.07)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C64(1.25)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.