Details of the Target

General Information of Target

Target ID LDTP04709
Target Name Paired box protein Pax-9 (PAX9)
Gene Name PAX9
Gene ID 5083
Synonyms
Paired box protein Pax-9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARY
NETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSV
SSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVP
AIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHA
VNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGH
GWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
Uniprot ID
P55771
Ensemble ID
ENST00000361487.7
HGNC ID
HGNC:8623

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C206(1.52)  LDD3354  [1]
Compound 10
 Probe Info  		N.A.  LDD2216  [2]
Compound 11
 Probe Info  		N.A.  LDD2213  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
Phosphinate-6
 Probe Info  		C52(0.00); C40(0.00)  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BICR-22 C206(1.29)  LDD2266  [1]
 LDCM0023  KB03 BICR-22 C206(2.42)  LDD2683  [1]
 LDCM0024  KB05 NCI-H2122 C206(1.52)  LDD3354  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 4 (KLF4) Krueppel C2H2-type zinc-finger protein family O43474
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004