Details of the Target

General Information of Target

Target ID LDTP04697
Target Name Cadherin-12 (CDH12)
Gene Name CDH12
Gene ID 1010
Synonyms
Cadherin-12; Brain cadherin; BR-cadherin; Neural type cadherin 2; N-cadherin 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQ
FFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDRE
EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL
QVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAK
DMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ
NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH
SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY
FIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL
DVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV
RDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS
CNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHY
DDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQR
LQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD
MFGEEESYNPDKVT
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Uniprot ID
P55289
Ensemble ID
ENST00000382254.6
HGNC ID
HGNC:1751

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC44 SNV: p.H41N .
HEC1B SNV: p.A496V .
HGC27 SNV: p.N680K .
HT29 SNV: p.Q24K .
IGR37 SNV: p.Q234Ter .
IGR39 SNV: p.Q234Ter .
IM95 SNV: p.V657A .
JHH7 SNV: p.L203F .
LS180 SNV: p.L608P .
MEWO SNV: p.L469W; p.S525F .
MOLT4 SNV: p.K53N; p.D188N .
NCIH23 SNV: p.P728T .
NCIH358 SNV: p.S374R; p.N602K .
NCIH716 SNV: p.K77T .
SUIT2 SNV: p.L621I .
SW1116 SNV: p.V569I .
TE1 SNV: p.T215S .
TE4 SNV: p.R690G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C699(1.74)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 FU-OV-1 C699(2.04)  LDD2328  [1]
 LDCM0023  KB03 ICC106 C699(2.40)  LDD2797  [1]
 LDCM0024  KB05 OV-90 C699(1.74)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840