Details of the Target

General Information of Target

Target ID LDTP04677
Target Name Microsomal triglyceride transfer protein large subunit (MTTP)
Gene Name MTTP
Gene ID 4547
Synonyms
MTP; Microsomal triglyceride transfer protein large subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
Target Type
Successful
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum
Function
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins.
TTD ID
T46628
Uniprot ID
P55157
DrugMap ID
TTUS1RD
Ensemble ID
ENST00000265517.10
HGNC ID
HGNC:7467
ChEMBL ID
CHEMBL2569

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.R121I .
A549 SNV: p.T203N .
AN3CA SNV: p.I347V .
CAL51 Deletion: p.H236QfsTer11 .
COLO792 SNV: p.A190V .
DU145 SNV: p.T40I .
HCT15 SNV: p.E683G .
MEWO SNV: p.K113Ter; p.P483L .
NCIH1155 SNV: p.Q254R .
NCIH2172 SNV: p.E343Q .
PANC0403 SNV: p.D736V .
RKO SNV: p.C878Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C397(0.00); C866(0.00); C445(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C301(2.15)  LDD3380  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HuH-1 C301(0.94)  LDD2374  [2]
 LDCM0023  KB03 HuH-1 C301(1.40)  LDD2791  [2]
 LDCM0024  KB05 OV-90 C301(2.15)  LDD3380  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein B-100 (APOB) . P04114

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-201038 Small molecular drug D0H8VY
Lomitapide Small molecular drug DB08827
Phase 2
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Granotapide Small molecular drug D0F2KX
Implitapide Small molecular drug D0F6YK
Jnj-16269110 Small molecular drug D0M5WS
Slx-4090 Small molecular drug D05YTG
Kd020 . D0S7AW
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dirlotapide Small molecular drug D0J0TP
Hesperetin Small molecular drug DB01094
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gr-328713 . D0SS6J

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840