Details of the Target

General Information of Target

Target ID LDTP04670
Target Name Microfibril-associated glycoprotein 4 (MFAP4)
Gene Name MFAP4
Gene ID 4239
Synonyms
Microfibril-associated glycoprotein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKALLALPLLLLLSTPPCAPQVSGIRGDALERFCLQQPLDCDDIYAQGYQSDGVYLIYPS
GPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWNDYKLGFGRADGEYWLGLQNMHLL
TLKQKYELRVDLEDFENNTAYAKYADFSISPNAVSAEEDGYTLFVAGFEDGGAGDSLSYH
SGQKFSTFDRDQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKG
FYYSLKRTEMKIRRA
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance.
Uniprot ID
P55083
Ensemble ID
ENST00000299610.5
HGNC ID
HGNC:7035

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB1 SNV: p.A29V .
JURKAT SNV: p.D193Y .
OVCAR5 SNV: p.C70F .
SKMEL30 SNV: p.D134N .
SNU1 SNV: p.I25T .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [1]

References

1 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.