Details of the Target
General Information of Target
| Target ID | LDTP04645 | |||||
|---|---|---|---|---|---|---|
| Target Name | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2) | |||||
| Gene Name | HMGCS2 | |||||
| Gene ID | 3158 | |||||
| Synonyms |
Hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase |
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| 3D Structure | ||||||
| Sequence |
MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE
VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM ESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYD FYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIF HTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKAS QDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASF FSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPG DTNSLFPGTWYLERVDEQHRRKYARRPV |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Thiolase-like superfamily, HMG-CoA synthase family
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| Subcellular location |
Mitochondrion
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| Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C261(2.13) | LDD3373 | [1] | |
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IPM Probe Info |
 |
C261(2.96) | LDD1701 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References