Details of the Target

General Information of Target

Target ID LDTP04644
Target Name UDP-glucuronosyltransferase 2B15 (UGT2B15)
Gene Name UGT2B15
Gene ID 7366
Synonyms
UGT2B8; UDP-glucuronosyltransferase 2B15; UDPGT 2B15; UGT2B15; EC 2.4.1.17; HLUG4; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UDPGTh-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD
Target Bioclass
Enzyme
Family
UDP-glycosyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils.
Uniprot ID
P54855
Ensemble ID
ENST00000338206.6
HGNC ID
HGNC:12546
ChEMBL ID
CHEMBL6161

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TER-AC
 Probe Info  		N.A.  LDD0426  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 22 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetaminophen Small molecular drug DB00316
Apomorphine Small molecular drug DB00714
Dabigatran Etexilate Small molecular drug DB06695
Delafloxacin Small molecular drug DB11943
Dextromethorphan Small molecular drug DB00514
Estradiol Small molecular drug DB00783
Ezetimibe Small molecular drug DB00973
Formoterol Small molecular drug DB00983
Fostemsavir Small molecular drug DB11796
Ibrexafungerp Small molecular drug DB12471
Lamotrigine Small molecular drug DB00555
Loratadine Small molecular drug DB00455
Lumateperone Small molecular drug DB06077
Morphine Small molecular drug DB00295
Pindolol Small molecular drug DB00960
Primidone Small molecular drug DB00794
Ritonavir Small molecular drug DB00503
Terbutaline Small molecular drug DB00871
Troglitazone Small molecular drug DB00197
Valproic Acid Small molecular drug DB00313
Enasidenib . DB13874
Viloxazine . DB09185
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Curcumin Sulfate . DB14635
Propacetamol . DB09288

References

1 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.