Details of the Target
General Information of Target
| Target ID | LDTP04628 | |||||
|---|---|---|---|---|---|---|
| Target Name | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A) | |||||
| Gene Name | PDE1A | |||||
| Gene ID | 5136 | |||||
| Synonyms |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; EC 3.1.4.17; 61 kDa Cam-PDE; hCam-1 |
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| 3D Structure | ||||||
| Sequence |
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
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| Function |
Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
 |
N.A. | LDD0025 | [1] | |
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JW-RF-010 Probe Info |
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N.A. | LDD0026 | [1] | |
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TFBX Probe Info |
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N.A. | LDD0027 | [1] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Transporter and channel
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Huntingtin (HTT) | Huntingtin family | P42858 | |||
The Drug(s) Related To This Target
Approved
| Drug Name | Drug Type | External ID | |||
|---|---|---|---|---|---|
| Bepridil | Small molecular drug | DB01244 | |||
| Caffeine | Small molecular drug | DB00201 | |||
| Felodipine | Small molecular drug | DB01023 | |||
| Nicardipine | Small molecular drug | DB00622 | |||
Investigative
| Drug Name | Drug Type | External ID | |||
|---|---|---|---|---|---|
| Sch51866 | Small molecular drug | D02VHD | |||
| Trapidil | Small molecular drug | DB09283 | |||