General Information of Target

Target ID LDTP04577
Target Name Beta-crystallin B1 (CRYBB1)
Gene Name CRYBB1
Gene ID 1414
Synonyms
Beta-crystallin B1; Beta-B1 crystallin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQAAKASASATVAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGNYR
LVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGE
YPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGFS
DRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLRDKQWHLE
GSFPVLATEPPK
Target Type
Literature-reported
Target Bioclass
Other
Family
Beta/gamma-crystallin family
Function Crystallins are the dominant structural components of the vertebrate eye lens.
TTD ID
T38622
Uniprot ID
P53674
DrugMap ID
TTDS503
Ensemble ID
ENST00000647684.1
HGNC ID
HGNC:2397

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C80(1.49)  LDD3411  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 KMS-27 C80(1.38)  LDD2424  [1]
 LDCM0023  KB03 KMS-12-BM C80(1.83)  LDD2840  [1]
 LDCM0024  KB05 RPMI-8226 C80(1.49)  LDD3411  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840