Details of the Target
General Information of Target
| Target ID | LDTP04538 | |||||
|---|---|---|---|---|---|---|
| Target Name | Stanniocalcin-1 (STC1) |
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| Gene Name | STC1 | |||||
| Gene ID | 6781 | |||||
| Synonyms |
STC; Stanniocalcin-1; STC-1 |
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| 3D Structure | ||||||
| Sequence |
MLQNSAVLLVLVISASATHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACL
ENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRM IAEVQEECYSKLNVCSIAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLECDEDTVSTIRD SLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEEDSPSHIK RTSHESA |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Family |
Stanniocalcin family
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| Subcellular location |
Secreted
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| Function | Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K93(10.00) | LDD0277 | [1] | |
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IPM Probe Info |
 |
N.A. | LDD0241 | [2] | |
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m-APA Probe Info |
 |
12.12 | LDD0403 | [3] | |
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DBIA Probe Info |
 |
C98(3.46); C45(2.19); C66(2.64) | LDD2268 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0156 | Aniline | NCI-H1299 | 12.12 | LDD0403 | [3] |
| LDCM0022 | KB02 | BRX211 | C98(3.46); C45(2.19); C66(2.64) | LDD2268 | [4] |
| LDCM0023 | KB03 | BRX211 | C98(7.20); C45(3.38); C66(2.42) | LDD2685 | [4] |
| LDCM0024 | KB05 | BRX211 | C98(5.58); C45(2.92); C66(4.22) | LDD3102 | [4] |
The Interaction Atlas With This Target
References