Details of the Target
General Information of Target
| Target ID | LDTP04528 | |||||
|---|---|---|---|---|---|---|
| Target Name | Beta-chimaerin (CHN2) | |||||
| Gene Name | CHN2 | |||||
| Gene ID | 1124 | |||||
| Synonyms |
ARHGAP3; BCH; Beta-chimaerin; Beta-chimerin; Rho GTPase-activating protein 3 |
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| 3D Structure | ||||||
| Sequence |
MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF
HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Subcellular location |
Membrane
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| Function |
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
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| TTD ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C91(2.39) | LDD3378 | [1] | |
Competitor(s) Related to This Target