Details of the Target

General Information of Target

Target ID LDTP04524
Target Name Zinc finger protein 135 (ZNF135)
Gene Name ZNF135
Gene ID 7694
Synonyms
ZNF61; ZNF78L1; Zinc finger protein 135; Zinc finger protein 61; Zinc finger protein 78-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTPGVRVSTDPEQVTFEDVVVGFSQEEWGQLKPAQRTLYRDVMLDTFRLLVSVGHWLPKP
NVISLLEQEAELWAVESRLPQGVYPDLETRPKVKLSVLKQGISEEISNSVILVERFLWDG
LWYCRGEDTEGHWEWSCESLESLAVPVAFTPVKTPVLEQWQRNGFGENISLNPDLPHQPM
TPERQSPHTWGTRGKREKPDLNVLQKTCVKEKPYKCQECGKAFSHSSALIEHHRTHTGER
PYECHECLKGFRNSSALTKHQRIHTGEKPYKCTQCGRTFNQIAPLIQHQRTHTGEKPYEC
SECGKSFSFRSSFSQHERTHTGEKPYECSECGKAFRQSIHLTQHLRIHTGEKPYQCGECG
KAFSHSSSLTKHQRIHTGEKPYECHECGKAFTQITPLIQHQRTHTGEKPYECGECGKAFS
QSTLLTEHRRIHTGEKPYGCNECGKTFSHSSSLSQHERTHTGEKPYECSQCGKAFRQSTH
LTQHQRIHTGEKPYECNDCGKAFSHSSSLTKHQRIHTGEKPYECNQCGRAFSQLAPLIQH
QRIHTGEKPYECNQCGRAFSQSSLLIEHQRIHTKEKPYGCNECGKSFSHSSSLSQHERTH
TGEKPYECHDCGKSFRQSTHLTQHRRIHTGEKPYACRDCGKAFTHSSSLTKHQRTHTG
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.
Uniprot ID
P52742
Ensemble ID
ENST00000313434.10
HGNC ID
HGNC:12919

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1954 SNV: p.R36T .
HCT116 SNV: p.Y123C .
HCT15 SNV: p.K333T .
HEC1 SNV: p.E183V .
HEC1B SNV: p.E183V .
HSC4 SNV: p.E582K .
IGR1 Substitution: p.G579E .
MEWO SNV: p.G82S; p.R570K .
MFE319 SNV: p.S312P .
NALM6 SNV: p.E327G .
SNGM SNV: p.D86A .
TE4 SNV: p.G360C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K268(0.00); K271(0.00); Y270(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010