Details of the Target

General Information of Target

Target ID LDTP04498
Target Name Rho-related GTP-binding protein RhoN (RND2)
Gene Name RND2
Gene ID 8153
Synonyms
ARHN; RHO7; Rho-related GTP-binding protein RhoN; Rho family GTPase 2; Rho-related GTP-binding protein Rho7; Rnd2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMW
DTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCPNAKVVLVGCK
LDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDVFHVATVA
SLGRGHRQLRRTDSRRGMQRSAQLSGRPDRGNEGEIHKDRAKSCNLM
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rho family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, acrosome membrane
Function May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily.
Uniprot ID
P52198
Ensemble ID
ENST00000587250.4
HGNC ID
HGNC:18315

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264