Details of the Target
General Information of Target
| Target ID | LDTP04481 | |||||
|---|---|---|---|---|---|---|
| Target Name | Transketolase-like protein 1 (TKTL1) | |||||
| Gene Name | TKTL1 | |||||
| Gene ID | 8277 | |||||
| Synonyms |
TKR; TKT2; Transketolase-like protein 1; EC 2.2.1.1; Transketolase 2; TK 2; Transketolase-related protein |
|||||
| 3D Structure | ||||||
| Sequence |
MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVL
FFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRV FCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAF GWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRER ADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALA KLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFA STFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIF YPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVI GAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQG GIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN |
|||||
| Target Type |
Literature-reported
|
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Transketolase family
|
|||||
| Subcellular location |
Cytoplasm
|
|||||
| Function |
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.; [Isoform 4]: During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG). bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons. bRG generate more cortical neurons over time than bIPs.
|
|||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C295(4.76); C472(1.39) | LDD3338 | [1] | |
|
IA-alkyne Probe Info |
 |
C391(0.70) | LDD2206 | [2] | |
|
Acrolein Probe Info |
 |
N.A. | LDD0223 | [3] | |
|
HHS-465 Probe Info |
 |
N.A. | LDD2240 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0022 | KB02 | Kelly | C472(1.47); C169(5.87) | LDD2417 | [1] |
| LDCM0023 | KB03 | GB-2 | C295(2.09) | LDD2752 | [1] |
| LDCM0024 | KB05 | MV4-11 | C295(4.76); C472(1.39) | LDD3338 | [1] |
| LDCM0109 | NEM | HeLa | N.A. | LDD0223 | [3] |
| LDCM0627 | NUDT7-COV-1 | HEK-293T | C391(0.70) | LDD2206 | [2] |
References