Details of the Target

General Information of Target

Target ID LDTP04480
Target Name Nuclear receptor subfamily 0 group B member 1 (NR0B1)
Gene Name NR0B1
Gene ID 190
Synonyms
AHC; DAX1; Nuclear receptor subfamily 0 group B member 1; DSS-AHC critical region on the X chromosome protein 1; Nuclear receptor DAX-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNV
ALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGL
PGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQR
PGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSS
GALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELA
QDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQA
IKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQ
GPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR0 subfamily
Subcellular location
Nucleus
Function
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.
TTD ID
T23191
Uniprot ID
P51843
DrugMap ID
TTTK36V
Ensemble ID
ENST00000378970.5
HGNC ID
HGNC:7960
ChEMBL ID
CHEMBL1795094

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.G106S .
MDAMB231 SNV: p.P160Q .
MELJUSO SNV: p.E164K .
NCIH1048 SNV: p.A194V .
NCIH358 SNV: p.Q283E .
REH SNV: p.P389L .
SW756 SNV: p.G182E; p.V253A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C104(5.64); C109(5.64); C107(5.64)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCT 116 C104(5.64); C109(5.64); C107(5.64)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C104(4.75); C109(4.75); C107(4.75)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C104(3.14); C109(3.14); C107(3.14)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT) EEF2KMT family Q96G04
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor ROR-alpha (RORA) Nuclear hormone receptor family P35398
Estrogen-related receptor gamma (ESRRG) Nuclear hormone receptor family P62508
Steroidogenic factor 1 (NR5A1) Nuclear hormone receptor family Q13285

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dexamethasone Small molecular drug DB01234
Dexamethasone Acetate . DB14649

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764