Details of the Target
General Information of Target
| Target ID | LDTP04460 | |||||
|---|---|---|---|---|---|---|
| Target Name | H(+)/Cl(-) exchange transporter 4 (CLCN4) | |||||
| Gene Name | CLCN4 | |||||
| Gene ID | 1183 | |||||
| Synonyms |
H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; ClC-4; Chloride transporter ClC-4 |
|||||
| 3D Structure | ||||||
| Sequence |
MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF
IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN |
|||||
| Target Bioclass |
Transporter and channel
|
|||||
| Family |
Chloride channel (TC 2.A.49) family, ClC-4/CLCN4 subfamily
|
|||||
| Subcellular location |
Early endosome membrane
|
|||||
| Function |
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| COLO792 | SNV: p.S672F | DBIA Probe Info | |||
| HCT15 | SNV: p.E281D | . | |||
| IM95 | SNV: p.M600V | DBIA Probe Info | |||
| MEWO | Substitution: p.P310L | DBIA Probe Info | |||
| MKN45 | SNV: p.E620K | DBIA Probe Info | |||
| NCIH1155 | SNV: p.V92M | . | |||
| SNGM | SNV: p.G580E | . | |||
| SW403 | SNV: p.V87F | . | |||
| WM2664 | Insertion: p.L279PfsTer36 | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C85(1.43) | LDD3332 | [1] | |
Competitor(s) Related to This Target