Details of the Target

General Information of Target

Target ID LDTP04418
Target Name Matrix metalloproteinase-16 (MMP16)
Gene Name MMP16
Gene ID 4325
Synonyms
C8orf57; MMPX2; Matrix metalloproteinase-16; MMP-16; EC 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM
SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY
ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR
DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL
FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT
RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF
KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ
PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVW
KGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVK
EGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCK
RSMQEWV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase M10A family
Subcellular location
Secreted, extracellular space, extracellular matrix; Cell membrane
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
TTD ID
T35824
Uniprot ID
P51512
DrugMap ID
TTNP4CU
Ensemble ID
ENST00000286614.11
HGNC ID
HGNC:7162
ChEMBL ID
CHEMBL2200

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.P198T .
COLO800 SNV: p.P58L .
CORL88 SNV: p.P317R .
DANG SNV: p.R149H .
DU145 SNV: p.G124V .
HCT15 SNV: p.R119L .
J82 Deletion: p.P146LfsTer17 .
KMCH1 SNV: p.H114R .
L428 SNV: p.R386W .
MCC13 SNV: p.G249E .
NCIH1155 SNV: p.Q604Ter .
NCIH1666 SNV: p.P307H .
NCIH1703 Deletion: p.P212LfsTer19 .
NCIH2172 SNV: p.P292T .
NCIH2286 SNV: p.R149S .
RPMI8226 SNV: p.K49T .
SUIT2 SNV: p.F199I .
SW1271 SNV: p.P308Q .
TE1 SNV: p.P378S .
WM115 SNV: p.P233L .
WM2664 SNV: p.P233L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C599(2.77)  LDD2469  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MGG123 C599(2.77)  LDD2469  [1]
 LDCM0023  KB03 MGG123 C599(6.25)  LDD2886  [1]
 LDCM0024  KB05 MGG123 C599(6.35)  LDD3303  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840