Details of the Target
General Information of Target
| Target ID | LDTP04411 | |||||
|---|---|---|---|---|---|---|
| Target Name | Death-associated protein 1 (DAP) |
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| Gene Name | DAP | |||||
| Gene ID | 1611 | |||||
| Synonyms |
DAP1; Death-associated protein 1; DAP-1 |
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| 3D Structure | ||||||
| Sequence |
MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPSPPKPTVFIS
GVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK |
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| Target Bioclass |
Other
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| Function |
Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo. Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STPyne Probe Info |
 |
K12(8.76); K20(7.95); K29(8.14); K88(7.69) | LDD0277 | [1] | |
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ATP probe Probe Info |
 |
K12(0.00); K29(0.00) | LDD0199 | [2] | |
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m-APA Probe Info |
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H79(0.00); H30(0.00) | LDD2231 | [3] | |
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1d-yne Probe Info |
 |
N.A. | LDD0358 | [4] | |
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Acrolein Probe Info |
 |
N.A. | LDD0217 | [5] | |
Competitor(s) Related to This Target
References