Details of the Target

General Information of Target

Target ID LDTP04380
Target Name Protein Tob1 (TOB1)
Gene Name TOB1
Gene ID 10140
Synonyms
TOB; TROB1; Protein Tob1; Transducer of erbB-2 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHI
GEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNEN
GCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTA
TFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQP
QQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSP
LQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN
Target Bioclass
Other
Family
BTG family
Subcellular location
Cytoplasm
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
Uniprot ID
P50616
Ensemble ID
ENST00000268957.3
HGNC ID
HGNC:11979

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0147  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C57(1.50)  LDD2227  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 7 (CNOT7) CAF1 family Q9UIV1
CCR4-NOT transcription complex subunit 6-like (CNOT6L) CCR4/nocturin family Q96LI5
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 1 (CNOT1) CNOT1 family A5YKK6
CCR4-NOT transcription complex subunit 3 (CNOT3) CNOT2/3/5 family O75175
Polyadenylate-binding protein 1 (PABPC1) Polyadenylate-binding protein type-1 family P11940
Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) RRM CPEB family Q8NE35
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) RRM CPEB family Q17RY0
Gelsolin (GSN) Villin/gelsolin family P06396
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264