Details of the Target

General Information of Target

Target ID LDTP04377
Target Name Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Gene Name TNFSF10
Gene ID 8743
Synonyms
APO2L; TRAIL; Tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD antigen CD253
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Family
Tumor necrosis factor family
Subcellular location
Cell membrane
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
TTD ID
T46084
Uniprot ID
P50591
DrugMap ID
TTA5MS9
Ensemble ID
ENST00000241261.7
HGNC ID
HGNC:11925
ChEMBL ID
CHEMBL5813

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.R191L .
HGC27 SNV: p.E173K .
SNU1 Deletion: p.Y182TfsTer15 .
SUPT1 Deletion: p.G246EfsTer15 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C56(4.36)  LDD3416  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C56(3.66)  LDD2247  [1]
 LDCM0023  KB03 786-O C56(5.71)  LDD2664  [1]
 LDCM0024  KB05 SCC-25 C56(4.36)  LDD3416  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840