Details of the Target
General Information of Target
| Target ID | LDTP04276 | |||||
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| Target Name | Steroidogenic acute regulatory protein, mitochondrial (STAR) |
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| Gene Name | STAR | |||||
| Gene ID | 6770 | |||||
| Synonyms |
STARD1; Steroidogenic acute regulatory protein, mitochondrial; StAR; START domain-containing protein 1; StARD1 |
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| 3D Structure | ||||||
| Sequence |
MLLATFKLCAGSSYRHMRNMKGLRQQAVMAISQELNRRALGGPTPSTWINQVRRRSSLLG
SRLEETLYSDQELAYLQQGEEAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVF RLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVG PRDFVSVRCAKRRGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLT WLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPASEARC |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Subcellular location |
Mitochondrion
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| Function |
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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STPyne Probe Info |
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K155(3.85) | LDD0277 | [1] | |